Article: Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.
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Kron M; Howell CJ; Adams IT; Ransbottom M; Christian D; Ogier M; Katz DM
J. Neurosci., 2012
Table 1.
Quantification of Fos expression in selected brain regions in Null vs Wt mice
Male Wt
Male Null
Medulla
n = 7
n = 7
Medial nTS
106.5 ± 0.5
326.4 ± 0.9***
Lateral nTS
137.9 ± 0.7
447.9 ± 2.0***
Commissural nTS
21.8 ± 0.2
53.4 ± 0.5*
Nucleus retroambiguus
7.9 ± 1.2
11.9 ± 2.2#
preBotzinger Complex
23.6 ± 7.4
29.1 ± 4.7
Pons
n = 5
n = 5
Pontine nucleus
322.7 ± 63.7
199.4 ± 51.5
Midbrain
n = 5
n = 5
Dorsal PAG
21.6 ± 32.8
13.9 ± 4.7
Lateral PAG
53.0 ± 25.2
35.9 ± 10.7#
Ventral PAG
39.7 ± 12.3
25.6 ± 7.5*
Forebrain
n = 5
n = 5
Piriform cortex
266.3 ± 35.0
124.2 ± 19.7*
Nucleus accumbens
114.4 ± 22.8
26.8 ± 7.9**
Cingulate cortex
50.4 ± 13.08
14.8 ± 4.8*
Retrosplenial cortex
39.7 ± 10.86
7.4 ± 1.6*
Prelimbic cortex
34.6 ± 6.81
8.4 ± 3.6**
Infralimbic cortex
26.6 ± 3.8
7.0 ± 2.2**
Motor cortex
19.9 ± 3.8
3.1 ± 1.6**
Lateral septal nucleus
48.6 ± 14.9
11.6 ± 4.9*
Hippocampus (CA1 + CA3)
22.5 ± 8.3
14.0 ± 4.6
Hippocampus (DG)
14.3 ± 4.7
9.5 ± 2.6
Inferred neuron-electrophysiology data values
Neuron Type
Neuron Description
Ephys Prop
Extracted Value
Standardized Value
Content Source